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Article

GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1.

Molecular and cellular biology - 1 Oct 2005

Kuhl Christiane, Atzberger Ann, Iborra Francisco, Nieswandt Bernhard, Porcher Catherine, Vyas Paresh

Abstract excerpt

The DNA-binding hemopoietic zinc finger transcription factor GATA1 promotes terminal megakaryocyte differentiation and restrains abnormal immature megakaryocyte expansion. How GATA1 coordinates these fundamental processes is unclear. Previous studies of synthetic and naturally occurring mutant GATA1 molecules demonstrate that DNA-binding and interaction with the essential GATA1 cofactor FOG-1 (via the N-terminal...

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Identifiers

PMID: 16166640
DOI: 10.1128/MCB.25.19.8592-8606.2005
PMCID: PMC1265752

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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