Article
Evidence that positive selection drives Y-chromosome degeneration in Drosophila miranda.
Nature genetics - 1 May 2004
Bachtrog Doris
Abstract excerpt
Why does the Y chromosome harbor so few functional loci? Evolutionary theory predicts that Y chromosomes degenerate because they lack genetic recombination. Both positive and negative selection models have been invoked to explain this degeneration, as both can result in the recurrent fixation of linked deleterious mutations on a nonrecombining Y chromosome. To distinguish between these models, I investigated...
Topics
- Animals
- Biological Evolution
- Chromosomes
- DNA
- Drosophila
- Genes, Insect
- Male
- Models, Genetic
- Mutation
- Recombination, Genetic
- Selection, Genetic
- Y Chromosome