Article
The advance of Muller's ratchet in a haploid asexual population: approximate solutions based on diffusion theory.
Genetical research - 1 Jun 1993
Stephan W, Chao L, Smale J G
Abstract excerpt
Asexual populations experiencing random genetic drift can accumulate an increasing number of deleterious mutations, a process called Muller's ratchet. We present here diffusion approximations for the rate at which Muller's ratchet advances in asexual haploid populations. The most important parameter of this process is n0 = N e-U/s, where N is population size, U the genomic mutation rate and s the selection...
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