Article

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles

2020-07-08

Abstract excerpt

Infections by parasitic nematodes inflict a huge burden on the health of humans and livestock throughout the world. Anthelmintic drugs are the first line of defense against these infections. Unfortunately, resistance to these drugs is rampant and continues to spread. To improve treatment strategies, we must understand the genetics and molecular mechanisms that underlie resistance. Studies of the fungus Aspergillu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c99e942f-2f77-5259-804c-23b244368bf4
DOI: 10.1101/2020.07.07.191866

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin allelesDOI 10.1101/2020.07.07.191866Read

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles.Semantic proximity Read

Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles.Semantic proximity Read

Extreme allelic heterogeneity at a <i>Caenorhabditis elegans</i> beta-tubulin locus explains natural resistance to benzimidazolesSemantic proximity Read

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles.Semantic proximity Read

Quantitative tests of albendazole resistance in beta-tubulin mutantsSemantic proximity Read

Benzimidazoles cause lethality by inhibiting the function of <i>Caenorhabditis elegans</i> neuronal beta-tubulinSemantic proximity Read

Interactions of <i>C. elegans</i> β-tubulins with the microtubule inhibitor albendazoleSemantic proximity Read

Quantitative tests of albendazole resistance in Caenorhabditis elegans beta-tubulin mutants.Semantic proximity Read

Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes.Semantic proximity Read

Discovery of unique loci that underlie nematode responses to benzimidazolesSemantic proximity Read

Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans.Semantic proximity Read

Mapping resistance-associated anthelmintic interactions in the model nematode <i>Caenorhabditis elegans</i>Semantic proximity Read