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Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1

18 May 2013

Abstract excerpt

Toxoplasma gondii is an important food and waterborne pathogen that causes severe disease in immunocompromised patients. Bumped kinase inhibitors (BKIs) have an antiparasitic effect on T. gondii tachyzoite growth by targeting T. gondii calmodulin-domain protein kinase 1 (TgCDPK1). To identify mutations that confer resistance to BKIs, chemical mutagenesis was performed, followed by selection in media containing...

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PMID: 24533298
DOI: 10.1016/j.ijpddr.2013.04.001

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Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1PMID 24533298Read ↗

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