Article
Towards compendia of negative genetic association studies: an example for Alzheimer disease.
Human genetics - 1 Mar 2006
Blomqvist Mia E-L, Reynolds Chandra, Katzov Hagit, Feuk Lars, Andreasen Niels, Bogdanovic Nenad, Blennow Kaj, Brookes Anthony J, Prince Jonathan A
Abstract excerpt
Most genetic sequence variants that contribute to variability in complex human traits will have small effects that are not readily detectable with population samples typically used in genetic association studies. A potentially valuable tool in the gene discovery process is meta-analysis of the accumulated published data, but in order to be valid these require a sample of studies representative of the true genetic...
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