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Article

A reappraisal of APOE genetic effects on Alzheimer's disease risk in the Japanese population: a meta-analysis.

Molecular neurodegeneration - 24 Jun 2026

Miyashita Akinori, Hara Norikazu, Obinata Ai, Tsukie Tamao, Hasegawa Mai, Ishiguro Takanobu, Kasuga Kensaku, Kikuchi Masataka, Hashimoto Tadafumi, Kanekiyo Takahisa, Ikeuchi Takeshi

Abstract excerpt

Our meta-analysis demonstrates that the risk effect of APOE-e4*4 relative to APOE-e3*3 for Alzheimer's disease in the Japanese population is approximately 12-15-fold, comparable to that reported in Caucasian populations, rather than greater than 20-fold as previously reported.

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Identifiers

PMID: 42337630
DOI: 10.1186/s13024-026-00963-z
PMCID: PMC13292320

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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