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Article

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

24 Aug 2018

Abstract excerpt

Anoikis is a form of apoptosis induced by cell detachment. Integrin inactivation plays a major role in the process but the exact signalling pathway is ill-defined. Here we identify an anoikis pathway using gliotoxin (GT), a virulence factor of the fungus Aspergillus fumigatus, which causes invasive aspergillosis in humans. GT prevents integrin binding to RGD-containing extracellular matrix components by...

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PMID: 30166526
DOI: 10.1038/s41467-018-05850-w

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