Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory.

Abstract excerpt

We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Behavior, Animal
• Share to Conditioning, Classical
• Share to Electroshock