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Article

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites.

Obesity (Silver Spring, Md.) - 1 Jan 2007

Prudente Sabrina, Chandalia Manisha, Morini Eleonora, Baratta Roberto, Dallapiccola Bruno, Abate Nicola, Frittitta Lucia, Trischitta Vincenzo

Abstract excerpt

This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI > or =40 kg/m2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different...

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Source

Identifiers

PMID: 17228024
DOI: 10.1038/oby.2007.636

Genes

ENPP1

Variants

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites.PMID 17228024Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.Semantic proximity Read ↗

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.Semantic proximity Read ↗

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.Semantic proximity Read ↗

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.Semantic proximity Read ↗

The role of K121Q ENPP1 polymorphism in diabetes mellitus and its complications.Semantic proximity Read ↗

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.Semantic proximity Read ↗

The K121Q polymorphism in ENPP1 (PC-1) is not associated with type 2 diabetes or obesity in Korean male workers.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.Semantic proximity Read ↗

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