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Article

Structural requirements of KTS-disintegrins for inhibition of alpha(1)beta(1) integrin.

The Biochemical journal - 1 Jan 2009

Brown Meghan C, Eble Johannes A, Calvete Juan J, Marcinkiewicz Cezary

Abstract excerpt

Obtustatin and viperistatin represent the shortest known snake venom monomeric disintegrins. In the present study, we have produced recombinant full-length wild-type and site-directed mutants of obtustatin to assess the role of the K(21)TS(23) tripeptide and C-terminal residues for specific inhibition of the alpha(1)beta(1) integrin. Thr(22) appeared to be the most critical residue for disintegrin activity,...

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Source

Identifiers

PMID: 18774946
DOI: 10.1042/BJ20081403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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