Article
Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin.
The Journal of biological chemistry - 15 Jul 1993
Lu W, Zhang W, Molloy S S, Thomas G, Ryan K, Chiang Y, Anderson S, Laskowski M
Abstract excerpt
Turkey ovomucoid third domain with Leu18 in its reactive site is a potent inhibitor of many serine proteinases: subtilisins, chymotrypsins, and elastases. Previous studies showed that an L18K mutation made it a moderately strong inhibitor of trypsin, while an L18E mutation made it a strong inhibi...
Topics
- Amino Acid Sequence
- Animals
- Furin
- Humans
- Molecular Sequence Data
- Mutation
- Ovomucin
- Peptide Fragments
- Subtilisins
- Turkeys