Article
Variation and evolution of biomolecular systems: searching for functional relevance.
FEBS letters - 21 Mar 2005
Huynen Martijn A, Gabaldón Toni, Snel Berend
Abstract excerpt
The availability of genome sequences and functional genomics data from multiple species enables us to compare the composition of biomolecular systems like biochemical pathways and protein complexes between species. Here, we review small- and large-scale, "genomics-based" approaches to biomolecular systems variation. In general, caution is required when comparing the results of bioinformatics analyses of genomes...
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