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Article

Contributions of multiple proteases to neurotoxicity in a mouse model of intracerebral haemorrhage.

Brain : a journal of neurology - 1 Jan 2009

Xue Mengzhou, Fan Yan, Liu Shuhong, Zygun David A, Demchuk Andrew, Yong V Wee

Abstract excerpt

Proteases such as matrix metalloproteinases (MMPs) and thrombin are implicated in intracerebral haemorrhage (ICH) but their interactions amongst one another and interdependency remain to be defined. The latter is important since proteases acting through different mechanisms to inflict neurotoxicity would require separate targeting compared with proteases acting through the same cascade. We reported recently that...

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PMID: 18772219
DOI: 10.1093/brain/awn215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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