Article
Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism.
Journal of the American College of Cardiology - 9 Sept 2008
Guo Ren, Chen Xiao-Ping, Guo Xin, Chen Lei, Li Dai, Peng Jun, Li Yuan-Jian
Abstract excerpt
OBJECTIVES: This study sought to determine whether calcitonin gene-related peptide (CGRP) is involved in glyceryl trinitrate (GTN) response in humans, and its association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. BACKGROUND: In animal models, CGRP contributes to the cardiovascular effects of GTN. The enzyme principally responsible for GTN bioactivation is ALDH2. The...
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