Article
Association study of calcitonin-receptor-like receptor gene in essential hypertension.
American journal of hypertension - 1 Mar 2005
Sano Morihiko, Kuroi Nobuhiro, Nakayama Tomohiro, Sato Naoyuki, Izumi Yoichi, Soma Masayoshi, Kokubun Shinichiro
Abstract excerpt
BACKGROUND: Plasma adrenomedullin (ADM) concentrations increase in patients with hypertension, renal failure, heart failure, essential pulmonary hypertension, myocardial infarction, endotoxin shock, and many other conditions. The ADM receptor is a complex molecule that consists of calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein 2 (RAMP2). Because CRLR determines the binding...
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