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Hamster Model of Leptospirosis

1 Sept 2006

Abstract excerpt

This unit describes the techniques involved in the hamster model of leptospirosis. Hamsters are exquisitely susceptible to infection with pathogenic Leptospira species. The LD(50) of virulent Leptospiral strains by intraperitoneal inoculation of 3- to 4-week-old hamsters is as low as a single organism. The pathogenesis of severe leptospirosis in the hamster is a model of accidental infections observed in nature...

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PMID: 18770576
DOI: 10.1002/9780471729259.mc12e02s02

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