Article
Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects.
European journal of clinical pharmacology - 1 Jan 2009
Liu Rui, Tang Audrey May Yi, Tan Yen Ling, Limenta Lie Michael George, Lee Edmund Jon Deoon
Abstract excerpt
OBJECTIVES: The aims of this study were to characterize the population frequency of PEPT2 (SLC15A2) polymorphic variants in three Asian ethnic populations, namely Chinese, Malay and Asian Indian, and to investigate the associations of ethnicity (Chinese vs. Asian Indian), PEPT2 haplotype and cephalexin pharmacokinetics in healthy Asian subjects. METHODS: PEPT2 polymorphisms were screened from a cohort of 96...
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