Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The extended tau haplotype and the age of onset of dementia in Down syndrome.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Jones Emma L, Margallo-Lana Marisa, Prasher Vee P, Ballard Clive G

Abstract excerpt

BACKGROUND/AIMS: Most people with Down syndrome (DS) develop Alzheimer's disease (AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS. METHODS: People with DS were assessed for dementia. Genotyping was performed for the extended tau haplotype, APOE and a polymorphism in APP, attt(5-8). RESULTS: Haplotype frequencies vary between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Haplotypes

Share to Risk Factors

Share to tau Proteins

Share to Young Adult

Source

Identifiers

PMID: 18765933
DOI: 10.1159/000152044

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The extended tau haplotype and the age of onset of dementia in Down syndrome.PMID 18765933Read ↗

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.Semantic proximity Read ↗

Common genetic signatures of Alzheimer’s disease in Down SyndromeSemantic proximity Read ↗

Alzheimer's disease in Down syndrome: An overlooked population for prevention trialsSemantic proximity Read ↗

Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome.Semantic proximity Read ↗

APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome.Semantic proximity Read ↗

Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome.Semantic proximity Read ↗

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodologySemantic proximity Read ↗

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read ↗

Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome.Semantic proximity Read ↗

From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approachSemantic proximity Read ↗

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.Semantic proximity Read ↗

Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.