Article
Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome.
Neurobiology of aging - 1 Oct 2013
Jones Emma L, Mok Kin, Hanney Marisa, Harold Denise, Sims Rebecca, Williams Julie, Ballard Clive
Abstract excerpt
It is known that individuals with Down syndrome develop Alzheimer's disease with an early age at onset, although associated genetic risk factors have not been widely studied. We tested whether genes that increase the risk of late-onset Alzheimer's disease influence the age at onset in Down syndrome using genome-wide association data for age at onset of dementia in a small sample of individuals (N = 67) with Down...
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