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Article

Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome.

Neurobiology of aging - 1 Oct 2013

Jones Emma L, Mok Kin, Hanney Marisa, Harold Denise, Sims Rebecca, Williams Julie, Ballard Clive

Abstract excerpt

It is known that individuals with Down syndrome develop Alzheimer's disease with an early age at onset, although associated genetic risk factors have not been widely studied. We tested whether genes that increase the risk of late-onset Alzheimer's disease influence the age at onset in Down syndro...

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Source

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Identifiers

PMID: 23601808
DOI: 10.1016/j.neurobiolaging.2013.03.018
PMCID: PMC3898582

Genes

PICALM
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23601808-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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