Article
Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Cancer cell - 16 Nov 2010
Skoulidis Ferdinandos, Cassidy Liam D, Pisupati Venkat, Jonasson Jon G, Bjarnason Hordur, Eyfjord Jorunn E, Karreth Florian A, Lim Michael, Barber Lorraine M, Clatworthy Susan A, Davies Susan E, Olive Kenneth P, Tuveson David A, Venkitaraman Ashok R
Abstract excerpt
Inherited heterozygous BRCA2 mutations predispose carriers to tissue-specific cancers, but somatic deletion of the wild-type allele is considered essential for carcinogenesis. We find in a murine model of familial pancreatic cancer that germline heterozygosity for a pathogenic Brca2 truncation suffices to promote pancreatic ductal adenocarcinomas (PDACs) driven by Kras(G12D), irrespective of Trp53 status....
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