Protein binding characterization of pethidine and norpethidine and lack of interethnic variability.

Abstract excerpt

Using dialysis, incubation experiments and gas liquid chromatographic method, we studied the binding of pethidine (P) and norpethidine (N) to various protein components and plasma of both healthy volunteers and patients. The displacement interactions and interethnic variations of P and N were also examined. The (mean +/- S.D.) plasma protein binding ranged from 72 +/- 2.8 to 43 +/- 2.7% and from 57 +/- 3.0 to 27...

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