Article
Protein binding characterization of pethidine and norpethidine and lack of interethnic variability.
Methods and findings in experimental and clinical pharmacology - 1 May 1991
Wong Y C, Chan K, Lau O W, Aun C, Houghton I T
Abstract excerpt
Using dialysis, incubation experiments and gas liquid chromatographic method, we studied the binding of pethidine (P) and norpethidine (N) to various protein components and plasma of both healthy volunteers and patients. The displacement interactions and interethnic variations of P and N were als...
Topics
- Analgesia
- Asian People
- Binding, Competitive
- Blood Proteins
- Cholinesterase Inhibitors
- Genetic Variation
- Humans
- Injections, Intramuscular
- Kinetics
- Male
- Meperidine
- Orosomucoid
- Protein Binding
- Serum Albumin
- White People