Article
Clopidogrel variability: role of plasma protein binding alterations.
British journal of clinical pharmacology - 1 Jun 2013
Ganesan Shobana, Williams Craig, Maslen Cheryl L, Cherala Ganesh
Abstract excerpt
AIM: The large inter-individual variability in clopidogrel response is attributed to pharmacokinetics. Although, it has been used since the late 1990s the pharmacokinetic fate of clopidogrel and its metabolites are poorly explained. The variable response to clopidogrel is believed to be multi-factorial, caused both by genetic and non-genetic factors. In this study, we examined whether the inactive metabolite can...
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