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Article

The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties.

The American journal of pathology - 1 Jul 2011

Montero-Melendez Trinidad, Patel Hetal B, Seed Michael, Nielsen Søren, Jonassen Thomas E N, Perretti Mauro

Abstract excerpt

Synthetic and natural melanocortin (MC) peptides afford inhibitory properties in inflammation and tissue injury, but characterization of receptor involvement is still elusive. We used the agonist AP214 to test MC-dependent anti-inflammatory effects. In zymosan peritonitis, treatment of mice with AP214 (400 to 800 μg/kg) inhibited cell infiltration, an effect retained in MC receptor type 1, or MC(1), mutant mice...

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Identifiers

PMID: 21703408
DOI: 10.1016/j.ajpath.2011.03.042
PMCID: PMC3123798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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