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Article

The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and Mouse

1 Oct 1997

Abstract excerpt

Human chromosome 15q11-q13 contains genes that are imprinted and expressed from only one parental allele. Prader-Willi syndrome (PWS) is due to the loss of expression of one or more paternally expressed genes on proximal human chromosome 15q, most often by deletion or maternal uniparental disomy. Several candidate genes and a putative imprinting centre have been identified in the deletion region. We report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9302265
DOI: 10.1093/hmg/6.11.1873

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The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and MousePMID 9302265Read ↗

The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region.Semantic proximity Read ↗

Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.Semantic proximity Read ↗

Disruption of the mouse necdin gene results in early post-natal lethality.Semantic proximity Read ↗

A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues.Semantic proximity Read ↗

The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal regionSemantic proximity Read ↗

Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during developmentSemantic proximity Read ↗

Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.Semantic proximity Read ↗

Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome.Semantic proximity Read ↗

Maternal imprinting of human SNRPN, a gene deleted in Prader-Willi syndrome.Semantic proximity Read ↗

Genetic abnormalities in Prader-Willi syndrome and lessons from mouse models.Semantic proximity Read ↗

A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center.Semantic proximity Read ↗

Novel paternally expressed intergenic transcripts at the mouse Prader-Willi/Angelman Syndrome locus.Semantic proximity Read ↗

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