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Article

Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.

Cancer letters - 8 Dec 2008

Praml Christian, Schulz Wolfgang, Claas Andreas, Mollenhauer Jan, Poustka Annemarie, Ackermann Rolf, Schwab Manfred, Henrich Kai-Oliver

Abstract excerpt

AFAR genes play a key role in the detoxification of the carcinogen Aflatoxin B(1) (AFB(1)). In the rat, Afar1 induction can prevent AFB(1)-induced liver cancer. It has been proposed that AFAR enzymes can metabolise endogenous diketones and dialdehydes that may be cytotoxic and/or genotoxic. Furthermore, human AFAR1 catalyses the rate limiting step in the synthesis of the neuromodulator gamma-hydroxybutyrate (GHB)...

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Identifiers

PMID: 18752886
DOI: 10.1016/j.canlet.2008.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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