Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.

Oncogene - 24 Jul 2003

Praml Christian, Savelyeva Larissa, Schwab Manfred

Abstract excerpt

Alterations of the distal portion of the short arm of chromosome 1 (1p) are among the earliest abnormalities of human colorectal tumours. Recently, we have cloned the Aflatoxin B1 aldehyde reductase (AFAR) gene from a smallest region of overlapping deletion that is frequently (48%) hemizygously deleted in sporadic colorectal cancer. AFAR is expressed in a broad range of tissues. Its closely related rat protein is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Reductase
Share to Blotting, Southern
Share to Chromosome Banding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 1

Share to Contig Mapping

Share to Cosmids

Share to Protein Biosynthesis

Share to Tissue Distribution

Source

Identifiers

PMID: 12879023
DOI: 10.1038/sj.onc.1206684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.PMID 12879023Read ↗

Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.Semantic proximity Read ↗

The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.Semantic proximity Read ↗

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13Semantic proximity Read ↗

Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod.Semantic proximity Read ↗

Genomic clustering of tRNA-specific adenosine deaminase ADAT1 and two tRNA synthetases.Semantic proximity Read ↗

Identification and Cloning of the Human Homolog (JAG1) of the RatJagged1Gene from the Alagille Syndrome Critical Region at 20p12Semantic proximity Read ↗

Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease).Semantic proximity Read ↗

Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP.Semantic proximity Read ↗

Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease.Semantic proximity Read ↗

Transcriptional Regulation and Biological Functions of Selenium-Binding Protein 1 in Colorectal Cancer In Vitro and in Nude Mouse XenograftsSemantic proximity Read ↗

Molecular Cloning, Genomic Organization, and Chromosomal Localization of an Additional Human Aldehyde Dehydrogenase Gene, ALDH6Semantic proximity Read ↗

Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related EnzymesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.