Article
CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid diseases.
Genetic testing - 1 Sept 2008
Yeşilkaya Ediz, Koç Altuğ, Bideci Aysun, Camurdan Orhun, Boyraz Mehmet, Erkal Ozgür, Ergun Mehmet Ali, Cinaz Peyami
Abstract excerpt
Two common forms of autoimmune thyroid diseases are Graves' disease and Hashimoto's thyroiditis. Cytotoxic T lymphocyte antigen 4 (CTLA4) encoded by the CTLA4 gene on chromosome 2q33 plays a role in susceptibility to Graves' disease and is probably important also for Hashimoto's thyroiditis as well as for the other endocrine autoimmune disorders. The CTLA4 locus is the only nonhuman leukocyte antigen locus that...
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