Article
Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.
Molecular microbiology - 1 Aug 1991
Laible G, Spratt B G, Hakenbeck R
Abstract excerpt
Penicillin resistance in pneumococci is due to the appearance of high molecular-weight penicillin-binding proteins (PBPs) that have reduced affinity for the antibiotic. We have compared the PBX 2x genes (pbpX) of one penicillin-susceptible and five penicillin-resistant clinical isolates of Strept...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Biological Evolution
- Carrier Proteins
- Genetic Variation
- Glycogen Debranching Enzyme System
- Hexosyltransferases
- Humans
- Molecular Sequence Data
- Muramoylpentapeptide Carboxypeptidase
- Penicillin Resistance
- Penicillin-Binding Proteins
- Peptidyl Transferases
- Pneumococcal Infections
- Recombination, Genetic
- Sequence Homology, Nucleic Acid
- Species Specificity