Article
T-lymphocyte-activating properties of epidermal antigen-presenting cells from normal and psoriatic skin: evidence that psoriatic epidermal antigen-presenting cells resemble cultured normal Langerhans cells.
The Journal of investigative dermatology - 1 Sept 1991
Demidem A, Taylor J R, Grammer S F, Streilein J W
Abstract excerpt
Fresh and cultured human Langerhans cells display disparate functional programs, based on their capacities to activate autologous and allogeneic T cells, and with respect to their susceptibility to inhibition by transforming growth factor-beta (TGF beta). We have compared the functional propertie...
Topics
- Aged
- Antigen-Presenting Cells
- Cells, Cultured
- Cyclosporins
- Epidermal Cells
- Humans
- Langerhans Cells
- Lymphocyte Activation
- Middle Aged
- Phenotype
- Psoriasis
- Skin
- T-Lymphocytes
- Transforming Growth Factor beta