Article
Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T-cell conjugates.
The Journal of investigative dermatology - 1 Jan 1995
Pope M, Betjes M G, Hirmand H, Hoffman L, Steinman R M
Abstract excerpt
Prior studies of mouse skin in organ culture have shown that dendritic cells selectively emigrate from the explants over 1-3 d. This emigration may model the movements of dendritic cells that can occur in situ, as in transplantation and contact sensitivity. In this study, we cultured explants of...
Topics
- Cell Communication
- Cell Movement
- Dendritic Cells
- Female
- Flow Cytometry
- Humans
- Immunologic Memory
- Leukocytes
- Microscopy, Phase-Contrast
- Organ Culture Techniques
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Skin
- T-Lymphocytes