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Article

ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways

4 Mar 2013

Abstract excerpt

ARID4A and ARID4B are homologous members of the ARID (AT-rich interaction domain) gene family. ARID4A and ARID4B physically interact with each other. ARID4A is a retinoblastoma (RB)-binding protein. Biological function of these interactions is still unknown. Here, we report that mice with complete deficiency of Arid4a, combined with haploinsufficiency of Arid4b (Arid4a(-/-)Arid4b(+/-)), showed progressive loss of...

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PMID: 23487765
DOI: 10.1073/pnas.1218318110

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