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Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2008

Zhang Jiang-Wei, Liu Yong, Zhao Jiu-Yang, Wang Li-Ming, Ge Guang-Bo, Gao Yang, Li Wei, Liu Hong-Tao, Liu Hui-Xin, Zhang Yan-Yan, Sun Jie, Yang Ling

Abstract excerpt

Medroxyprogesterone acetate (MPA) is one of the most frequently prescribed progestins for conception, hormone replacement therapy, and adjuvant endocrine therapy. MPA has a low oral bioavailability because of extensive metabolism; however, its metabolism was poorly documented. This study was intended to profile the phase I metabolites of MPA and the cytochrome P450 (P450) isoforms involved. After MPA was...

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PMID: 18725509
DOI: 10.1124/dmd.108.022525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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