Article
Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland.
Biochimica et biophysica acta - 28 Nov 1993
Ichikawa-Haraguchi M, Sumizawa T, Yoshimura A, Furukawa T, Hiramoto S, Sugita M, Akiyama S
Abstract excerpt
P-glycoprotein (P-gp) is a transmembrane glycoprotein responsible for the multidrug resistant (MDR) phenotype in various cancer cells. It has been shown that P-gp transports various kinds of anti-cancer agents as well as hydrophobic chemicals. Although P-gp is also expressed in normal human tissu...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adrenal Glands
- Animals
- Binding Sites
- Biological Transport
- Carrier Proteins
- Cattle
- Drug Resistance
- Humans
- Membrane Glycoproteins
- Phenotype
- Pregnenolone
- Progesterone
- Tumor Cells, Cultured
- Vinblastine
- Vincristine