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Article

Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L mutation.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Apr 2008

Hamel Mary J, Poe Amanda, Bloland Peter, McCollum Andrea, Zhou Zhiyong, Shi Ya Ping, Ouma Peter, Otieno Kephas, Vulule John, Escalante Ananias, Udhayakumar Venkatachalam, Slutsker Laurence

Abstract excerpt

Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured the effect of co-trimoxazole (CTX) prophylaxis on P. falciparum antifolate resistance development among HIV-infected persons. HIV-positive patients with CD4 cell count < 350 cells/microl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18321547
DOI: 10.1016/j.trstmh.2008.01.018

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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