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Article

Co-expression of cytokeratin 8 and breast cancer resistant protein indicates a multifactorial drug-resistant phenotype in human breast cancer cell line.

Life sciences - 26 Sept 2008

Liu Fang, Fan Dongmei, Qi Jing, Zhu Huifang, Zhou Yuan, Yang Chunzheng, Zhu Zhenping, Xiong Dongsheng

Abstract excerpt

AIMS: The aim was to determine whether increased CK8 and BCRP expression cooperatively contribute to multidrug resistance (MDR) in MCF-7/MX cells. Accumulating evidence suggests that the development and maintenance of cancer MDR involves complex multimodal mechanisms that interact concomitantly and complementarily. In this report, we observed elevated expression of cytokeratin 8 (CK8) in MCF-7/MX, a mitoxantrone...

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Identifiers

PMID: 18725232
DOI: 10.1016/j.lfs.2008.07.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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