Article
Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the alpha(1b)-adrenoceptor.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2000
Knauber J, Müller W E
Abstract excerpt
There is growing evidence that a dysfunction of central noradrenergic neurotransmission is involved in age-related impairments of cognitive performance and the pathophysiology of Alzheimer's disease (AD). A reduction of density of central alpha(1)-adrenergic receptors (alpha(1)-AR) has been shown...
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