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A minimally instrumented method for the detection of rifampicin resistance-causing mutations in Mycobacterium tuberculosis utilizing lateral flow readout.

Analytica chimica acta - 8 Jul 2025

Chauhan Ayushi, SivaKumar S, Toley Bhushan J

Abstract excerpt

BACKGROUND: Genotypic methods for detecting antimicrobial resistance in Mycobacterium tuberculosis (M.tb) typically require expensive instrumentation, limiting their accessibility in peripheral and resource-limited settings. Rifampicin resistance is a key marker of multidrug-resistant tuberculosis (MDR-TB) and is primarily caused by mutations in the rpoB gene. Rapid, cost-effective, and minimally instrumented...

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Bacterial Proteins
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

Tuberculosis, Multidrug-Resistant

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PMID: 40374243
DOI: 10.1016/j.aca.2025.344090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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