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Article

Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice.

Neurobiology of disease - 1 Nov 2008

Rocher Anne B, Kinson Michael S, Luebke Jennifer I

Abstract excerpt

Amyloid-beta (Abeta) plays a key role in the etiology of Alzheimer's disease, and pyramidal cell dendrites exposed to Abeta exhibit dramatic structural alterations, including reduced dendritic spine densities. To determine whether such structural alterations lead to electrophysiological changes, whole-cell patch clamp recordings with biocytin filling were used to assess both the electrophysiological and...

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Identifiers

PMID: 18721884
DOI: 10.1016/j.nbd.2008.07.014
PMCID: PMC2683422

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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