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Article

Position of single amino acid substitutions in the collagen triple helix determines their effect on structure of collagen fibrils.

Journal of structural biology - 1 Dec 2004

Steplewski Andrzej, Ito Hidetoshi, Rucker Eileen, Brittingham Raymond J, Alabyeva Tatiana, Gandhi Milind, Ko Frank K, Birk David E, Jimenez Sergio A, Fertala Andrzej

Abstract excerpt

Collagen II fibrils are a critical structural component of the extracellular matrix of cartilage providing the tissue with its unique biomechanical properties. The self-assembly of collagen molecules into fibrils is a spontaneous process that depends on site-specific binding between specific domains belonging to interacting molecules. These interactions can be altered by mutations in the COL2A1 gene found in...

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PMID: 15522781
DOI: 10.1016/j.jsb.2004.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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