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Article

ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons.

Scientific reports - 14 Sept 2016

Liu Zhiying, Zang Yunjin, Qiao Luxin, Liu Kai, Ouyang Yabo, Zhang Yulin, Chen Dexi

Abstract excerpt

The mechanisms behind HIV-1-associated neurocognitive disorders are still unclear. Apoptosis-stimulating protein 2 of p53 (ASPP2) is a damage-inducible p53-binding protein that stimulates p53-mediated apoptosis and transactivates proapoptotic and cell cycle regulatory genes. It has been reported that ASPP2 has a specific regulatory function in the death of retinal ganglion cells and the development of Alzheimer's...

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Identifiers

PMID: 27625111
DOI: 10.1038/srep33378
PMCID: PMC5022057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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