Article
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Human molecular genetics - 1 Dec 2008
Royer-Zemmour Barbara, Ponsole-Lenfant Magali, Gara Hyam, Roll Patrice, Lévêque Christian, Massacrier Annick, Ferracci Géraldine, Cillario Jennifer, Robaglia-Schlupp Andrée, Vincentelli Renaud, Cau Pierre, Szepetowski Pierre
Abstract excerpt
Mutations in SRPX2 (Sushi-Repeat Protein, X-linked 2) cause rolandic epilepsy with speech impairment (RESDX syndrome) or with altered development of the speech cortex (bilateral perisylvian polymicrogyria). The physiological roles of SRPX2 remain unknown to date. One way to infer the function of SRPX2 relies on the identification of the as yet unknown SRPX2 protein partners. Using a combination of interactome...
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