SRPX2 mutations in disorders of language cortex and cognition.

doi:10.1093/hmg/ddl035

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Article

SRPX2 mutations in disorders of language cortex and cognition.

Human molecular genetics - 1 Apr 2006

Roll Patrice, Rudolf Gabrielle, Pereira Sandrine, Royer Barbara, Scheffer Ingrid E, Massacrier Annick, Valenti Maria-Paola, Roeckel-Trevisiol Nathalie, Jamali Sarah, Beclin Christophe, Seegmuller Caroline, Metz-Lutz Marie-Noëlle, Lemainque Arnaud, Delepine Marc, Caloustian Christophe, de Saint Martin Anne, Bruneau Nadine, Depétris Danièle, Mattéi Marie-Geneviève, Flori Elisabeth, Robaglia-Schlupp Andrée, Lévy Nicolas, Neubauer Bernd A, Ravid Rivka, Marescaux Christian, Berkovic Samuel F, Hirsch Edouard, Lathrop Mark, Cau Pierre, Szepetowski Pierre

Abstract excerpt

The rolandic and sylvian fissures divide the human cerebral hemispheres and the adjacent areas participate in speech processing. The relationship of rolandic (sylvian) seizure disorders with speech and cognitive impairments is well known, albeit poorly understood. We have identified the Xq22 gene SRPX2 as being responsible for rolandic seizures (RSs) associated with oral and speech dyspraxia and mental...

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PMID: 16497722
DOI: 10.1093/hmg/ddl035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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