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Article

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.

BMC genetics - 18 Oct 2007

Royer Barbara, Soares Dinesh C, Barlow Paul N, Bontrop Ronald E, Roll Patrice, Robaglia-Schlupp Andrée, Blancher Antoine, Levasseur Anthony, Cau Pierre, Pontarotti Pierre, Szepetowski Pierre

Abstract excerpt

BACKGROUND: The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent...

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PMID: 17942002
DOI: 10.1186/1471-2156-8-72
PMCID: PMC2151080

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Source receipt: pubmed, retrieved 7 Sept 2026.

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