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Article

Cell and cytokine imbalances in rheumatoid synovitis.

Joint bone spine - 1 May 2011

Boissier Marie-Christophe

Abstract excerpt

Rheumatoid synovitis is a complex process in which systemic and local homeostatic dysregulation is expressed in the joint. The main genetic susceptibility factors are HLA-DRB1 alleles containing the shared epitope. Environmental factors predominate over genetic factors in the pathogenesis of rheumatoid arthritis (RA), and among them smoking is the most powerful. In RA, disruptions in self-tolerance lead to...

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Identifiers

PMID: 20961791
DOI: 10.1016/j.jbspin.2010.08.017

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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