Article
Integration of RNA processing and expression level control modulates the function of the Drosophila Hox gene Ultrabithorax during adult development.
Development (Cambridge, England) - 1 Jan 2011
de Navas Luis F, Reed Hilary, Akam Michael, Barrio Rosa, Alonso Claudio R, Sánchez-Herrero Ernesto
Abstract excerpt
Although most metazoan genes undergo alternative splicing, the functional relevance of the majority of alternative splicing products is still unknown. Here we explore this problem in the Drosophila Hox gene Ultrabithorax (Ubx). Ubx produces a family of six protein isoforms through alternative splicing. To investigate the functional specificity of the Ubx isoforms, we studied their role during the formation of the...
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