Article
Systematic analysis of stutters to enhance the accuracy of chimerism testing.
Annals of clinical and laboratory science - 1 Jan 2008
Chen Ding-Ping, Tseng Ching-Ping, Tsai Shu-Hui, Wu Tsu-Lan, Chang Pi-Yueh, Sun Chien-Feng
Abstract excerpt
Post-transplantation chimerism testing is important to monitor the engraftment of donor stem cells and for the diagnosis of relapse. Detecting the presence of donor/recipient-specific short tandem repeats (STRs) is a frequently used method for engraftment study. Unfortunately, the interpretation of the STR-based chimerism tests is often subject to interference by the presence of a stutter peak, which is one...
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