Article
Selection of high-avidity CD8 T cells correlates with control of hepatitis C virus infection.
Hepatology (Baltimore, Md.) - 1 Sept 2008
Neveu Bérangère, Debeaupuis Emilie, Echasserieau Klara, le Moullac-Vaidye Béatrice, Gassin Michelle, Jegou Loïg, Decalf Jérémie, Albert Matthew, Ferry Nicolas, Gournay Jérôme, Houssaint Elisabeth, Bonneville Marc, Saulquin Xavier
Abstract excerpt
UNLABELLED: Both strong antigenic avidity and acquisition of proper effector functions contribute to the efficacy of antiviral T cell responses. To correlate these parameters with the outcome of hepatitis C virus (HCV) infection, we characterized HCV-specific CD8 T cell lines isolated after immunomagnetic sorting of peripheral blood mononuclear cells from human leukocyte antigen A*02 (HLA-A*02) individuals with...
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