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Article

A study of the mu opioid receptor gene polymorphism A118G in patients with primary biliary cirrhosis with and without pruritus.

Acta dermato-venereologica - 1 Jan 2008

Wei Lin Xiang, Floreani Annarosa, Floriani Annarosa, Variola Angella, El Younis Cherif, Bergasa Nora V

Abstract excerpt

The increase in opioidergic tone by the central administration of morphine, which binds to the mu opioid receptor, is associated with pruritus. Pruritus is a symptom of cholestasis, which appears to result, in part, from increased opioidergic tone; a central mechanism has been proposed. The single nucleotide polymorphism Al18G in exon 1 of the opioid receptor mu 1 (OPRM1) gene, which codes for the mu opioid...

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Share to OPRM1 gene
Share to Liver Cirrhosis, Biliary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

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Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 18709298
DOI: 10.2340/00015555-0436

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A study of the mu opioid receptor gene polymorphism A118G in patients with primary biliary cirrhosis with and without pruritus.PMID 18709298Read ↗

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