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Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates.

Toxins - 2 Oct 2020

Khan Muzaffar A, Dashevsky Daniel, Kerkkamp Harald, Kordiš Dušan, de Bakker Merijn A G, Wouters Roel, van Thiel Jory, Op den Brouw Bianca, Vonk Freek, Kini R Manjunatha, Nazir Jawad, Fry Bryan G, Richardson Michael K

Abstract excerpt

Venomous snakes are important subjects of study in evolution, ecology, and biomedicine. Many venomous snakes have alpha-neurotoxins (α-neurotoxins) in their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction, causing paralysis and asphyxia. Several venomous snakes and their predators have evolved resistance to α-neurotoxins. The resistance is conferred by...

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Identifiers

PMID: 33023159
DOI: 10.3390/toxins12100638
PMCID: PMC7601176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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